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|Section2= |Section3= }} Echinocandin B, a lipopeptide, is a naturally occurring cyclic hexapeptide with a linoleoyl side chain. It belongs to a class of antifungal agents called echinocandins, which inhibits the synthesis of glucan, a major component of the fungal cell wall, via noncompetitive inhibition of a crucial enzyme, β-(1,3)-D-glucan synthase. Echinocandin B is a fermentation product of ''Aspergillus nidulans'' and the closely related species, ''A. rugulosus''; discovered in 1974 in ''A. nidulans'' var. ''echinulatus'' strain A 32204 in Germany, it was the first of the echinocandin class of antifungals. Echninocandin B can undergo deacylation (removal of the lipid side chain) by the action of a deacylase enzyme from the filamentous bacterium ''Actinoplanes utahensis'', which catalyzes the cleavage of the linoleoyl side chain; in three subsequent synthetic steps, including a chemical reacylation, the antifungal drug anidulafungin〔(【引用サイトリンク】title=Anidulafungin EMA Europa )〕 is synthesized. == References == 〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Echinocandin B」の詳細全文を読む スポンサード リンク
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